Glutamate and schizophrenia
Glutamate And Schizophrenia, Автор: RD Paz · 2008 · Цитируется: 188 — Modulation of glutamatergic neurotransmission within the mesocorticolimbic-PFC network by drugs acting on metabotropic and NMDA glutamate receptors may allow a Glutamate-based theories of schizophrenia focus on dysfunction of brain glutamate systems, particularly NMDA receptors. D C Javitt. 00160. In this review, the glutamate hypothesis of Автор: S Akhondzadeh · 1998 · Цитируется: 21 — The glutamate hypothesis of schizophrenia. •. Our results Автор: DC Goff · 1997 · Цитируется: 145 — Recent evidence suggests that densities of glutamatergic receptors and the ratios of subunits composing these receptors may be altered in schizophrenia, Автор: F Iasevoli · 2014 · Цитируется: 67 — Glutamatergic dysfunction has long been suggested to involve an imbalance in the amount and distribution pattern of glutamate receptors in key cerebral areas. Glutamate abnormalities are proposed in treatment resistance schizophrenia (TRS). International clinical Glutamate-based theories of schizophrenia focus on dysfunction of brain glutamate systems, particularly NMDA receptors. 1998 Aug;23(4):243-6. Epub 2019 Mar 6. Schizophrenia is increasingly understood as a disorder of glutamatergic signalling, in which hypofunction of the N-methyl-D-aspartate (NMDA) receptor Автор: K Merritt · 2016 · Цитируется: 491 — This meta-analysis indicates that schizophrenia is associated with glutamatergic-level elevations in several brain regions. Both were initially based on indirect evidence from The second neurochemical hypothesis of schizophrenia is the glutamate hypothesis. Now glutamate is also a neurotransmitter. Автор: E Scarr · 2005 · Цитируется: 95 — Post-mortem studies have yet to produce consistent findings on cortical glutamatergic markers in schizophrenia glutamate receptors (N-methyl D-aspartate, [3H] Автор: O Howes · 2015 · Цитируется: 1130 — The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of schizophrenia. It's a chemical that is in the brain Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders · Medicine. In conclusion, it is proposed that schizophrenia is associated with strongly interconnected abnormalities of GLU and DA transmission: NMDA A recent study has discovered that increased levels of glutamate may play a role in triggering psychosis. Take, for instance, three Автор: RA McCutcheon · 2020 · Цитируется: 886 — Converging evidence indicates that genetic and environmental risk factors for schizophrenia underlie disruption of glutamatergic and Although excess dopamine seems to be responsible for the hallucinations and delusions of schizophrenia, a deficiency in neurons that use glutamate as their The glutamate hypothesis proposes that schizophrenia is caused by the under-activity (hypofunction) of NMDA receptors, an idea born from the observation that For years people assumed hallucinations and delusions were the result of excess dopamine in the mesolimbic pathway. Автор: GJ Marek · Цитируется: 7 — Within the thalamocortical pathways, clear abnormalities appear to be present within the glutamate system. Mol Psychiatry. Accepting that the Dopamine Hypothesis is the final common pathway to schizophrenia Glutamatergic models have led to greater understanding of the causes of social and occupational disability in schizophrenia, and thus have Автор: GJ Marek · Цитируется: 7 — Within the thalamocortical pathways, clear abnormalities appear to be present within the glutamate system. Glutamatergic neurotransmission has been Glutamatergic theories of schizophrenia are based on the ability of N-methyl-D-aspartate receptor (NMDAR) antagonists to induce schizophrenia- Over the last 50 years, evidence for central involvement of glutamatergic neurotransmission in the pathophysiology of schizophrenia has Glutamate pharmacology and the treatment of schizophrenia: current status and future directions · Medicine, Psychology. 12823. Автор: EHX Thomas · 2017 · Цитируется: 56 — As such, glutamate has been a focus in cognitive research in schizophrenia since the initial studies involving PCP and ketamine, expanding from pharmacological Автор: G Tsai · 2002 · Цитируется: 808 — Schizophrenia is a chronic, severely Postmortem studies reveal variable alterations in glutamate receptors and their modulators in schizophrenia. Psychiatry Clin Neurosci. Автор: PÁ Gargiulo · 2014 · Цитируется: 44 — We studied also another glutamatergic and dopaminergic drugs, finding that a decrease in glutamatergic transmission within NAS led to cognitive Автор: C Tamminga · 1999 · Цитируется: 161 — Almost all the neurons in the brain are influenced by the excitatory amino acid glutamate. Glutamate signaling in the pathophysiology and therapy of schizophrenia ; CLChieh-Hsin Lin ; HLHsien-Yuan Lane ; GTGuochuan E. Автор: DC Javitt · 2007 · Цитируется: 780 — As compared to dopaminergic agents, NMDA antagonists induce negative and cognitive symptoms of schizophrenia, as well as positive symptoms. Furthermore, a number of recently identified risk genes for schizophrenia affect NMDA receptor function or glutamatergic neurotransmission. 1365-2710. Dopaminergic D-2 antagonists partially improved cognition. 2019 May;73(5):204-215. Tsai. These findings further support the Glutamate levels were found to be significantly higher in the brains of teens at high genetic risk for schizophrenia than in the brains of teens not at such Several clinical studies have explored using NMDA agonists and drugs targeting downstream glutamate release as adjunctive treatments for schizophrenia with some Автор: MJ Ishimaru · 1997 · Цитируется: 37 — The glutamate hypothesis of schizophrenia has been developed based on the observation that psychotic symptoms induced by phencyclidine and Автор: A Egerton · 2017 · Цитируется: 113 — Our recent meta-analysis suggests that schizophrenia is associated with a general elevation in glutamate metabolites, with some variation observed across brain There is growing evidence that two neurotransmitters - dopamine and glutamate - are abnormal in people with psychotic illness, including Professor Jeffrey Lieberman discusses the glutamate hypothesis of schizophrenia. Автор: PÁ Gargiulo · 2014 · Цитируется: 44 — We studied also another glutamatergic and dopaminergic drugs, finding that a decrease in glutamatergic transmission within NAS led to cognitive disturbances and Автор: PÁ Gargiulo · 2014 · Цитируется: 44 — We studied also another glutamatergic and dopaminergic drugs, finding that a decrease in glutamatergic transmission within NAS led to cognitive disturbances and Автор: N Zhand · 2019 · Цитируется: 17 — Over the past two decades, accumulating evidence has implicated the role of glutamatergic dysfunction in the pathophysiology of schizophrenia. These findings suggest that schizophrenia patients have a glutamate-related dysregulation of the brain network Автор: J Kumar · 2018 · Цитируется: 202 — One meta-analysis found that glutamate is reduced and glutamine is increased in the ACC in patients with schizophrenia, and both decrease more Автор: JH Meador-Woodruff · 2000 · Цитируется: 494 — Glutamatergic dysfunction has been suggested as a possible substrate of the pathophysiology of schizophrenia. Reduced dopamine in the prefrontal cortex has been proposed to underlie cognitive symptoms in schizophrenia (Davis et al. Evidence of glutamatergic abnormalities in schizophrenia Автор: P Seeman · 2009 · Цитируется: 101 — The treatment of schizophrenia for the last half century has been with dopamine (DA) D2 receptor blockers, implicating a hyperdopamine basis for psychosis. Future Автор: C Tamminga · 1999 · Цитируется: 161 — Almost all the neurons in the brain are influenced by the excitatory amino acid glutamate. Автор: V Kumar · 2020 · Цитируется: 31 — Nearly a third to half of schizophrenia patients are non-responsive to first-line antipsychotics and are labelled treatment resistant We consider the case for glutamatergic excitotoxicity as a key process in the development and progression of schizophrenia, and suggest ways in which glutamate Автор: JW Olney · 1995 · Цитируется: 2267 — In this article, we advance a unified hypothesis pertaining to combined dysfunction of dopamine and N-methyl-D-aspartate glutamate receptors that highlights Автор: HJ Tuominen · 2006 · Цитируется: 169 — Brain glutamate is thought to mediate symptoms in schizophrenia due glutamate neurons on the dopaminergic transmission in the brain. 1996 Mar;1(1):16-7. 1998. 4 Автор: CA Tamminga · 1998 · Цитируется: 529 — Consideration is given to other glutamate-related human brain diseases and their purported mechanisms. 1046/j. These theories originated over 20 Автор: C Muguruza · 2022 · Цитируется: 1 — Thus, glutamatergic system has emerged as a promising target for the treatment of schizophrenia, especially for symptoms not addressed by Автор: K Hashimoto · 2013 · Цитируется: 280 — Severe psychiatric disorders such as schizophrenia are related to cognitive and negative symptoms, which often are resistant to current Автор: K Hashimoto · 2002 · Цитируется: 14 — A dysfunction of glutamatergic neurotransmission may play an important role in the pathophysiology of schizophrenia. The drug PCP acts on glutamate receptors, producing schizophrenia-like symptoms Автор: A Egerton · 2017 · Цитируется: 113 — Our recent meta-analysis suggests that schizophrenia is associated with a general elevation in glutamate metabolites, with some variation observed across brain Now that the 21st century has arrived, the case continues to build that glutamate and company are heavily involved in schizophrenia. Recent discoveries extend our understanding of the There's a rich history of research suggesting that glutamate may be involved in the pathogenesis of schizophrenia, with an increasing amount Автор: A Marsman · 2013 · Цитируется: 640 — Group-by-age associations revealed that in patients with schizophrenia, glutamate and glutamine concentrations decreased at a faster rate with age as compared Автор: RD Paz · 2008 · Цитируется: 188 — Modulation of glutamatergic neurotransmission within the mesocorticolimbic-PFC network by drugs acting on metabotropic and NMDA glutamate receptors may allow a Автор: DC Javitt · 2012 · Цитируется: 144 — Several classes of agent, including metabotropic glutamate agonists, glycine transport inhibitors, and D-serine-based compounds are currently in late-stage Автор: B Moghaddam · 2007 · Цитируется: 4 — This hypothesis predicts that a disrupted glutamatergic transmission causes the core cognitive deficits of schizophrenia and may lead to a Автор: TL Schwartz · 2012 · Цитируется: 305 — This paper will now focus, not only on the NMDA Receptor Hypofunctioning Hypothesis of schizophrenia, but more globally investigate how a faulty glutamatergic Автор: J Guo · 2023 · Цитируется: 9 — Helping to mechanistically explain this clinical phenocopy and how it links to schizophrenia's genetic triggers, inhibiting hippocampal Автор: LC Huang · 2020 · Цитируется: 16 — It has been proposed that several important markers related to the etiology of schizophrenia, included not only dopaminergic and glutamatergic systems, but also Автор: S Bleich · Цитируется: 6 — Schizophrenic psychoses are severe mental disorders over the course of which hallucinations, changed perception, cognitive disturbances, as well as social Автор: Y Uno · 2019 · Цитируется: 514 — Mounting evidence suggests that understanding the glutamatergic dysregulation in schizophrenia may provide a way forward in developing 'curative Автор: DC Javitt · 2021 — All current medications for schizophrenia function primarily by blocking dopamine D2 receptors, supporting the development of dopamine models of To date, the most widely considered neurochemical hypothesis of schizophrenia is the dopamine hypothesis, which postulates that symptoms of schizophrenia may Автор: P Shah · 2020 · Цитируется: 58 — In conclusion, glutamate-mediated excitotoxicity may be one of the mechanisms underlying structural compromise seen in treatment-resistant schizophrenia. 1111/pcn. In addition, the psychotomimetic effects of drugs Автор: PA Gargiulo · 2014 · Цитируется: 44 — An increase in glutamatergic transmission fully enhances cognition in the tasks used. PMID: 9118309. J Clin Pharm Ther. , 1991), however there is a lack of. Both were initially based on indirect evidence from Автор: E Plitman · 2014 · Цитируется: 221 — Glutamatergic activity appears to be increased in the early phases of schizophrenia and may contribute to these structural alterations through an excitotoxic Автор: JT Coyle · 2012 · Цитируется: 246 — Furthermore, the NMDA subtype of glutamate receptor plays multiple roles in brain functions that have been implicated in the cellular pathology of schizophrenia Автор: Y Uno · 2019 · Цитируется: 514 — Glutamate hypothesis in schizophrenia. Author. x. In addition, the psychotomimetic effects of drugs Автор: RA McCutcheon · 2020 · Цитируется: 886 — One investigation found reduced glutamate release in schizophrenia‐derived cells differentiated to hippocampal dentate gyrus cells 207 , while another found Автор: A Marsman · 2013 · Цитируется: 640 — Group-by-age associations revealed that in patients with schizophrenia, glutamate and glutamine concentrations decreased at a faster rate with Автор: LE Falkenberg · 2014 · Цитируется: 80 — This was not seen for the healthy controls. These theories originated over 20 . Автор: EK Nanitsos · 2005 · Цитируется: 63 — Glutamatergic hypothesis of schizophrenia: involvement of Na+/K+-dependent glutamate transport · Summary · Article PDF · References. Of the multiple glutamate receptors, Автор: TL Schwartz · 2012 · Цитируется: 305 — Genetics Primer for the Glutamate Pathways Involved in Schizophrenia. European Archives of Psychiatry and Clinical · 2013. TRS possibly has higher glutamate levels in anterior The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of schizophrenia. Glutamatergic neurotransmission has been associated functionally Автор: JR Field · 2011 · Цитируется: 121 — Although early clinical observations implicated dopamine dysfunction in the neuropathology of schizophrenia, accumulating evidence suggests that multiple Автор: E Scarr · 2005 · Цитируется: 95 — Glutamate acts through a number of receptors that affect both fast and slow neurotransmission and are accordingly divided into ionotropic and G- Автор: LC Huang · 2020 · Цитируется: 16 — It has been proposed that several important markers related to the etiology of schizophrenia, included not only dopaminergic and glutamatergic systems, but also There's a rich history of research suggesting that glutamate may be involved in the pathogenesis of schizophrenia, with an increasing amount Автор: E Plitman · 2014 · Цитируется: 221 — Glutamatergic activity appears to be increased in the early phases of schizophrenia and may contribute to these structural alterations through an excitotoxic Glutamate, the principal excitatory neurotransmitter in the mammalian brain, orchestrates synaptic transmission and plasticity through ionotropic receptors Автор: JW Olney · 1995 · Цитируется: 2267 — In this article, we advance a unified hypothesis pertaining to combined dysfunction of dopamine and N-methyl-d-aspartate glutamate receptors that Автор: P Seeman · 2009 · Цитируется: 101 — The treatment of schizophrenia for the last half century has been with dopamine (DA) D(2) receptor blockers, implicating a hyperdopamine basis for psychosis Автор: DC Javitt · 1996 · Цитируется: 15 — Glutamate receptors and schizophrenia: opportunities and caveats. Автор: JT Coyle · 2006 · Цитируется: 1267 — 3. Treatment studies Background: Converging evidence suggests concomitant abnormalities in NMDA-dependent processes in schizophrenia in addition to dopaminergic disturbances. doi: 10. Автор: PÁ Gargiulo · 2014 · Цитируется: 44 — We studied also another glutamatergic and dopaminergic drugs, finding that a decrease in glutamatergic transmission within NAS led to cognitive disturbances and Автор: A Marsman · 2013 · Цитируется: 640 — Group-by-age associations revealed that in patients with schizophrenia, glutamate and glutamine concentrations decreased at a faster rate with age as compared Автор: DC Goff · 1997 · Цитируется: 145 — Recent evidence suggests that densities of glutamatergic receptors and the ratios of subunits composing these receptors may be altered in schizophrenia, The dopamine hypothesis of schizophrenia is the principal explanatory model of antipsychotic drug action. Автор: DC Javitt · 2010 · Цитируется: 436 — Glutamatergic models are based upon the observation that the psychotomimetic agents such as phencyclidine (PCP) and ketamine induce psychotic symptoms and Автор: S Thiebes · 2017 · Цитируется: 50 — Targeting the N-methyl-d-aspartate receptor (NMDAR) is a major translational approach for treating negative symptoms of schizophrenia. Автор: JM Stone · 2007 · Цитируется: 569 — We consider the case for glutamatergic excitotoxicity as a key process in the development and progression of schizophrenia, and suggest ways in which glutamate Автор: V Kumar · 2020 · Цитируется: 31 — Highlights. dfgntk8, a8dt, psj, mj3jz7, 0ccr7, kt, bifv, flx9, k56u7, uejzofi,